مسار بولونيا
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نسرين جلال محمد البياتي

السنة عنوان البحث نشر البحث
2020 Possible protective effect of Zucchini juice against nephrotoxicity induced by cisplatin in mice Ann Trop Med & Public Health
Cisplatin (CP) is a widely used anti-cancer drug that is commonly administered for the treatment of various cancers. However, nephrotoxicity is the most important adverse effect of this drug which limits its use. Aim of the present study was inspection of the possible protective effect of zucchini juice against CP-induced nephrotoxicity. In this experimental study mice were equally divided into three groups: the positive control group (CP only treated group), control group (distilled water only treated group) and zucchini juice group (CP plus zucchini juice treated group), then the biochemical (blood urea and serum creatinine) and histological examination were done. Results revealed that the renal indices (blood urea & serum creatinine) in the positive control group were increased high significantly (p ≤ 0.001) in comparison to the control group and zucchini juice received group, while no significant difference was found between control group & zucchini juice treated group (p ≥ 0.05), also histopathological assessment of kidney's sections taken from mice of the positive control group revealed that there were diffuse renal tubular necrosis and infiltration of inflammatory cells as compared to the normal renal tubules that were appeared in the kidney's sections taken from mice of the control group. While no histopathological changes were seen during the examination of histopathological sections of kidney's mice of the zucchini juice group as compared to the histopathological sections of the kidneys taken from mice belong to the positive control group and control group. In conclusion zucchini seems to have a protective effect against nephrotoxicity induced by CP.