مسار بولونيا
EN

أحمد محمد عبدالظاهر ربيع

السنة عنوان البحث نشر البحث
2022 Comparativeevaluationofdifferentmathematicalmodelsfor simultaneousUVspectrophotometricquantitativeanalysisofvelpatasvir andsofosbuvir Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Velpatasvirandsofosbuvirarenewdrugsprescribedinacombinedpharmaceuticaldosageformthat poseanewchallengefor thetreatmentofchronichepatitisC. Inthiswork, acomparativeevaluation of theclassicalmathematicalmodel, simultaneousequations, andtheadvancedmathematicalmodel, partial leastsquares, for thespectrophotometricquantitativeanalysisofvelpatasvirandsofosbuvir in bulkpowderandinthenewcombinedpharmaceuticaldosageformwaspresented.Themathematical simultaneousequationmethodwasusedtoresolve theoverlapbetweenvelpatasvirandsofosbuvir. Theabsorbanceandabsorbativityvaluesat255and244.8wereusedtoconstruct twomathematical equationsrequiredforspectrophotometricquantitativeanalysisof thedrugsunderstudy.Partial least squares,anadvancedmathematicaltooldealingwiththefullspectraldataofvelpatasvirandsofosbuvir, wasalsointroduced.Anexperimentaldesignforthecalibrationsetsandvalidationsetsforthebinary mixtureof thedrugsunderstudywerecreated.Themodelwasoptimizedbasedonafive-level, two factorexperimentaldesign.Pre-processingofthespectraldatawasappliedandresultedintheexclusion ofthespectralregionfrom200to230nmduetonoise.Thedescribedmethodsweresuccessfullyapplied tothespectrophotometricquantitativeanalysisofvelpatasvirandsofosbuvirinEpclusa tablets.