جامعة الكوت - University of kut - بحوث زينب حسين طه

السنة	عنوان البحث	نشر البحث
2026	The Role of Interleukin-6 in the Pathogenesis and Progression of Hepatitis B Virus Infection	Kut University Journal
Abstract The hepatitis- B virus, (HBV) is the cause of hepatitis- B, a serious worldwide health issue and potentially fatal liver infection. This study was conducted in Wasit Province, Iraq, in collaboration with the microbiology unit of Alkarama Hospital and Alzahraa Hospital. The purpose of this study was to assess interleukin-6 (IL-6) serum levels and the protective function of this cytokine in HBV-infected patients. Samples were gathered throughout the province of Wasit. It contained 22 healthy participants as a control group and 66 blood samples from Iraqi patients infected with HBV. The study was carried out between December 2024 and February 2025. Both groups' ages ranged from 14 to 72. There were 22 patients in the mild group, 22 in the intermediate group, and 22 in the severe group. All subjects had serum samples taken, and ELISA (enzyme linked immunosorbent assay) was used to determine the cytokine levels. A blood test toolkit will include all of these tools. Samples with and without HBV showed significant variations in the means of the three variables that were chosen. For all three variables under investigation, the computed P-value was less than 0.001. But as an inflammatory mediator, IL-6 also contributes to the progression of HBVinduced liver cirrhosis and exacerbates liver damage. All things considered, the available evidence suggests that IL-6 functions in HBV infection as an immune-regulatory cytokine. Patients with HBV have elevated serum levels of IL-6. Furthermore, there is a favorable correlation between the severity of the disease and blood IL-6 levels.