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2025 Estimation of Serum Level of Neurokinin Ain Patients with Per-iodontitis in Association with Chronic Migraine Disease (Obser-vational Case Control Study CENTRAL ASIAN JOURNAL OF MEDICALANDNATURALSCIENCES
The increased level of serum NKA in the control group when compared to other study groups suggests a role for NKA as a neuropeptide in both chronic migraine and periodontitis. Furthermore, there was a weak negative significant correlation between NKA and all clinical periodontal parameters that might suggest a direct association with disease severity and activity.Limitations:The most important limitation is age and sex were matched for the per-iodontitis group and migraine with periodontitis only because of difficulty in finding the exact criteria among patients and limited time of sampling (not more than 6 months). In-deed, the present study is a case control study that show association but not the causality